TCEN-49, a monoclonal antibody that identifies a central body antigen in the planarian Dugesia (Girardia) tigrina. Implications for pattern formation and positional signalling mechanisms |
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Authors: | David Bueno Lluis Espinosa Marc Aureli Soriano Eduard Batlle Jaume Baguñà Rafael Romero |
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Affiliation: | (1) Department de Genética, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 645, Barcelona, 08071 Catalonia, Spain |
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Abstract: | We have produced monoclonal antibodies (mAbs) against antigens of the freshwater planarian Dugesia (G.) tigrina (Girard) using standard protocols. One of these mAbs, TCEN-49, detects an antigen (TCEN-49Ag) present in most cells of the central area of the body, including the pharynx. Labelled cells seem more related by position than by lineage, suggesting that TCEN-49Ag is involved somehow in the expression of central body positional identity. The spatial and temporal changes in TCEN-49Ag expression during growth/degrowth and regeneration have been monitored and the implications of these results are discussed. |
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Keywords: | monoclonal antibodies regional antigen regeneration pattern formation immunohistochemistry Dugesia (G.) tigrina |
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