Concentrations of trace elements in osteoarthritic knee-joint effusions |
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Authors: | Michael Krachler Wolfgang Domej Kurt J Irgolic |
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Institution: | (1) Institute for Analytical Chemistry, Karl-Franzens-University Graz, A-8010 Graz, Austria;(2) Department of Medicine, Karl-Franzens-University Graz, A-8010 Graz, Austria;(3) Research Centre Juelich, Institute of Applied Physical Chemistry, D-52425 Juelich, Germany |
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Abstract: | Concentrations of the 18 elements, barium (Ba), beryllium (Be), bismuth (Bi), calcium (Ca), cadmium (Cd), cesium (Cs), copper
(Cu), lanthanum (La), lithium (Li), magnesium (Mg), molybdenum (Mo), lead (Pb), rubidium (Rb), antimony (Sb), tin (Sn), strontium
(Sr), thallium (Tl), and zinc (Zn), were determined in the synovial fluids of osteoarthritic knee joints and in the corresponding
sera of 16 patients by inductively coupled plasma-mass spectrometry. Knee-joint effusions have lower elemental concentrations
than their corresponding sera. For the essential elements Ca, Cu, Mg, and Zn and for the nonessential and toxic elements Ba,
Be, Bi, La, and Sb, this difference was highly significant. Strong positive correlations between concentrations in effusions
and sera for the essential elements Cu and Mg and for the nonessential elements Cs, Li, Rb, and Sr could be established. The
grade of localized hyperperfusion of the knee region in the blood pool phase of 99mTc HDP bone scan indicating inflammation did not correlate with any elemental concentration determined.
Deceased. |
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Keywords: | Osteoarthritis trace elements synovial fluid knee effusions serum ICP-MS |
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