Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum |
| |
| Authors: | Kuranaga E Kanuka H Furuhata Y Yonezawa T Suzuki M Nishihara M Takahashi M |
| |
| Institution: | Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan. |
| |
| Abstract: | Apoptosis in corpus luteum (CL) is induced by prolactin (PRL) in female rats. PRL-induced apoptosis in CL is mediated by the Fas/Fas ligand (FasL) system. The CL consists of steroidogenic and non-steroidogenic cells, including immunocytes. Fas mRNA was detected only in the luteal steroidogenic cells, and FasL mRNA was expressed only by the non-steroidogenic CD3-positive luteal immunocytes. Removing the luteal immune cells from the luteal cells inhibited PRL-induced luteal cell apoptosis effectively. Thus, FasL-expressing non-steroidogenic luteal immunocytes are required for PRL-induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas/FasL in CL. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
