Synergistic Effects of Trace Amounts of Water in the Enantiodiscrimination Processes by Lipodex E: A Spectroscopic and Computational Investigation |
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| Authors: | Gloria Uccello‐Barretta Volker Schurig Federica Balzano Letizia Vanni Federica Aiello Mattia Mori Francesca Ghirga |
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| Institution: | 1. Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy;2. Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany;3. Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy;4. Department of Chemistry and Drug Technology, Sapienza University, Rome, Italy |
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| Abstract: | Nuclear magnetic resonance (NMR) investigations on mixtures containing octakis(3‐O‐butanoyl‐2,6‐di‐O‐pentyl)‐γ‐cyclodextrin (Lipodex E) and each enantiomer of methyl‐2‐chloropropionate (MCP) ascertained the role of trace amounts of water in the enantiodiscrimination processes. Water is deeply included into the cyclodextrin and favors the formation of the inclusion complex with (S)‐MCP, whereas (R)‐MCP is only slightly affected, thus causing a significant increase of NMR differentiation. Molecular dynamics simulations were performed to shed light on the possible behavior of Lipodex E in different conditions (i.e., solvent, inclusion complexes), providing energetic and atomistic details that are in agreement with NMR observations. Chirality 27:95–103, 2014. © 2014 Wiley Periodicals, Inc. |
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| Keywords: | NMR spectroscopy chirality host‐guest systems molecular dynamics cyclodextrins |
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