An Improved and Efficient Process for the Preparation of (+)‐cloprostenol |
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| Authors: | Yi Chen Hui Yan Hui‐Xuan Chen Jiang Weng Gui Lu |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Sun Yat‐sen University, Guangzhou, China;2. Institute of Human Virology, Sun Yat‐sen University, Guangzhou, China |
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| Abstract: | An improved and efficient synthesis of (+)‐cloprostenol has been accomplished in nine steps and 26% overall yield from commercially available (–)‐Corey lactone 4‐phenylbenzoate alcohol 1 . The present route avoids tedious purifications and requires only one column chromatography operation, which reduces the generation of waste and is suitable for large‐scale preparation. Chirality 27:392–396, 2015. © 2015 Wiley Periodicals, Inc. |
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| Keywords: | Corey lactone prostaglandin (+)‐cloprostenol synthesis process development asymmetric reduction |
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