Enantioseparation of the Six Important Intermediates of Homoharringtonine With Immobilized Cellulose Chiral Stationary Phase |
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Authors: | Jie Zhou Qiuzheng Du Fang Sun Qian Liu Zhenzhong Zhang |
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Institution: | 1. School of Pharmacy, Zhengzhou University, Zhengzhou, Henan, P.R. China;2. Key Laboratory of State Ministry of Education for Pharmaceutical Technology, Zhengzhou, Henan, P.R. China |
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Abstract: | A new liquid chromatographic method has been developed for the chiral separation of the enantiomers of intermediates in the preparation of the ester side‐chain of homoharringtonine. The enantiomers were separated by a Chiralpak IC (250 × 4.6 mm, 5 µm) in normal phase high‐performance liquid chromatography (HPLC). Four compounds were baseline resolved. By comparing the chromatographs of racemates and single enantiomers of the six intermediates, the enantiomeric excess values of the single enantiomers were evaluated, and the elution orders of the enantiomers were established. Chirality 27:538–542, 2015. © 2015 Wiley Periodicals, Inc. |
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Keywords: | chiralpak IC e e values enantiomeric separation homoharringtonine HPLC |
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