Systemic Neurochemical Alterations in Schizophrenic Brain: Glutamate Metabolism in Focus |
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Authors: | Gulnur Sh Burbaeva Irina S Boksha Elena B Tereshkina Olga K Savushkina Lubov’ I Starodubtseva Marina S Turishcheva Elizabeta Mukaetova-Ladinska |
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Institution: | (1) Laboratory of Neurochemistry, Mental Health Research Center, Russian Academy of Medical Sciences, 2-2 Zagorodnoje shosse, 117152 Moscow, Russia;(2) Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK |
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Abstract: | We have used a systemic approach to establish a relationship between enzyme measures of glial glutamate and energy metabolism
(glutamine synthetase and glutamine synthetase-like protein, glutamate dehydrogenase isoenzymes, brain isoform creatine phosphokinase)
and two major glial proteins (glial fibrillary acidic protein and myelin basic protein) in autopsied brain samples taken from
patients with schizophrenia (SCH) and mentally healthy subjects (23 and 22 cases, respectively). These biochemical parameters
were measured in tissue extracts in three brain areas (prefrontal cortex, caudate nucleus, and cerebellum). Significant differences
in the level of at least one of the glutamate metabolizing enzymes were observed between two studied groups in all studied
brain areas. Different patterns of correlative links between the biochemical parameters were found in healthy and schizophrenic
brains. These findings give a new perspective to our understanding of the impaired regulation of enzyme levels in the brain
in SCH. |
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Keywords: | Schizophrenia Postmortem brain tissue Systemic approach Prefrontal cortex Caudate nucleus Cerebellum Glia Glutamate metabolism Energy metabolism Glutamine synthetase Glutamine synthetase-like protein Glutamate dehydrogenase isoenzymes Creatine phosphokinase Glial fibrillary acidic protein Myelin basic protein ECL-Western immunoblotting |
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