Buffalo (<Emphasis Type="Italic">Bubalus bubalis</Emphasis>) Epiphyseal Proteins Counteract Arsenic-Induced Oxidative Stress in Brain,Heart, and Liver of Female Rats |
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Authors: | Vijay K Bharti R S Srivastava B Sharma J K Malik |
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Institution: | Neurophysiology Laboratory Division of Physiology & Climatology, Indian Veterinary Research Institute, Izatnagar, 243122 Uttar Pradesh, India. vijaykbharti@rediffmail.com |
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Abstract: | Arsenic (As) toxicity through induction of oxidative stress is a well-known mechanism of organ toxicity. To address this problem,
buffalo epiphyseal proteins (BEP, at 100 μg/kg BW, i.p. for 28 days) were administered intraperitoneally to female Wistar
rats exposed to As (100 ppm sodium arsenite via drinking water for 28 days). Arsenic exposure resulted in marked elevation
in lipid peroxidation in brain, cardiac, and hepatic tissues, whereas significant (p < 0.05) adverse change in catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, and reduced glutathione
level were observed in cardiac, hepatic, and brain tissues of As-administered animals. BEP significantly (p < 0.05) counteracted all the adverse changes in antioxidant defense system brought about by As administration. Based on these
results, we consider BEP as a potent antioxidant to be used for protection from arsenic-induced oxidative stress related damage
of vital organs. |
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