|
|||||
|
|
| 别嘌醇对高尿酸血症大鼠血清脂联素的影响 | |
| 引用本文： | 赵平,张向阳,卢福建,尚伟民,李冰,李塨. 别嘌醇对高尿酸血症大鼠血清脂联素的影响[J]. 中国实验动物学报, 2011, 19(6): 530-533,I0004. DOI: 10.3969/j.issn.1005-4847.2011.06.016 |
| 作者姓名： | 赵平 张向阳 卢福建 尚伟民 李冰 李塨 |
| 作者单位： | 1. 新疆医科大学第一附属医院心脏中心,乌鲁木齐市,830054 2. 河南省长葛市人民医院心内科,河南长葛市,461500 3. 中国石油管道局第三工程公司职工医院,郑州,451450 4. 平顶山市第二人民医院心内科,河南平顶山,467000 |
| 摘 要： | 目的观察高尿酸血症大鼠血清脂联素的改变,探讨别嘌醇对高尿酸血症大鼠血清脂联素的影响及意义。方法 36只雄性SD大鼠随机分为3组。使用高酵母膏饲料联合氧嗪酸钾混悬液腹腔注射6周诱导大鼠高尿酸血症模型。别嘌醇治疗组除给予造模剂外同时给予别嘌醇灌胃。6周后处死大鼠,检测血清尿酸、脂联素、一氧化氮,免疫组化法检测大鼠主动脉内膜层eNOS的表达量。结果与正常对照组相比模型组大鼠血尿酸显著升高[(216.0±6.2)vs(45.1±5.6),P<0.05],血清脂联素、一氧化氮及主动内膜层内皮型一氧化氮合酶表达量显著降低[(52.6±7.9)vs(63.6±9.2),(17.2±3.3)vs(24.1±2.0),(38.3±4.5)vs(48.3±4.2),P<0.05]。别嘌醇治疗组血尿酸降低[(44.8±4.3)vs(216.0±6.2),P<0.05],血清脂联素和一氧化氮水平升高[(159.6±9.2)vs(52.6±7.9),(22.1±2.2)vs(17.2±3.3),P<0.05],主动脉内膜内皮型一氧化氮合酶蛋白表达增加[(46.1±4.2)vs(38.3±4.5),P<0.05]。脂联素与一氧化氮呈正相关(r=0.057),与血尿酸呈负相关(r=-0.48)。结论别嘌醇处理可一定程度逆转高尿酸血症可诱导的大鼠血清脂联素的降低,别嘌醇可能是上调内皮型一氧化氮合酶的激动剂。 |
| 关 键 词： | 高尿酸血症 脂联素 别嘌醇 一氧化氮 |
Influence of allopurinol treatment on serum adiponectin in hyperuricemia rats |
|
| ZHAO Ping,ZHANG Xiang-Yang,LU Fu-jiang,SHANG Wei-min,LI Bing,LI Gong. Influence of allopurinol treatment on serum adiponectin in hyperuricemia rats[J]. Acta Laboratorium Animalis Scientia Sinica, 2011, 19(6): 530-533,I0004. DOI: 10.3969/j.issn.1005-4847.2011.06.016 | |
| Authors: | ZHAO Ping ZHANG Xiang-Yang LU Fu-jiang SHANG Wei-min LI Bing LI Gong |
| Affiliation: | ZHAO Ping1,ZHANG Xiang-Yang1,LU Fu-jiang 2,SHANG Wei-min2,LI Bing3,LI Gong4(1.Heart Center of the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China,2.Cardiology Department of Changge People's Hospital of Henan,Changge 461500,3.Hospital staff of the Third Engineering Company of China Petroleum Pipeline Bureau,Zhengzhou 451450,4.Cardiology Department of The Second People's Hospital of Pingdingshan,Pingdingshan 467000) |
| Abstract: | Objective To investigate the change of serum adiponectin(APN) in hyperuricemia rats and to explore the influence of allopurinol treatment on serum APN and its implication in hyperuricemia rats.Methods Thirty-six male Sprague-Dawley(SD) rats were randomly divided into 3 groups.Hyperuricemia was induced in rats over 6 wk by a high-yeast extract(YE) diet combined with intraperitoneal injection of potassium oxonate(OA) suspension(n=12).Allopurinol was administered simultaneously with the OA and YE in allopurino... |
| Keywords: | Hyperuricemia Adiponectin Allopurinol Nitric oxide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |