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| 大鼠心肌梗死模型建立方法选择及心电图表现 | |
| 引用本文： | 王勇,高大中,殷跃辉,佘强,高翠菊,赵江龙,谭勇,唐永岗,陈运清,李攀.大鼠心肌梗死模型建立方法选择及心电图表现[J].中国实验动物学报,2011,19(6):525-529,I0004. |
| 作者姓名： | 王勇 高大中 殷跃辉 佘强 高翠菊 赵江龙 谭勇 唐永岗 陈运清 李攀 |
| 作者单位： | 1. 重庆市第七人民医院心内科,重庆,400054 2. 重庆医科大学第二附属医院心内科,重庆,400010 3. 重钢总院心内科,重庆,400080 4. 宝鸡市人民医院心内科,宝鸡,721000 5. 重庆医科大学超声影像学研究所,重庆,400010 |
| 基金项目： | 重庆市卫生局中医药科研资助项目 |
| 摘 要： | 目的探讨构建心肌梗死模型的大鼠左冠状动脉结扎位置及心电图特点。方法 SD大鼠经麻醉后,气管切开插管及连通呼吸机,打开左侧胸腔后分别在距离左心耳尖端约2 mm水平处(低位结扎组)与在距主动脉根部约3 mm处(高位结扎组)结扎左冠动脉,假手术组除不结扎冠脉外步骤同低位结扎组,术前术后分别行心电图检查,且4周后取出心脏行病理学检查及测定心肌梗死面积。结果高位结扎组大鼠心肌梗死面积约55.5%,总存活率13.3%;低位结扎组大鼠心肌梗死面积约36.2%,总存活率66.7%;假手术组大鼠无心肌梗死,存活率100%。大鼠体表心电图在非心肌梗死者QRS-T波群呈成"M"型波,在心肌梗死者R波与T波融合成高大的帐篷状单波,无明显ST段。4周后心肌组织形态学特点符合心肌梗死的病理改变。结论距大鼠主动脉根部约3 mm结扎左冠状动脉,不能满足实验需要;距离左心耳尖端约2 mm水平结扎左冠状动脉,能满足实验需要;大鼠的体表心电图无明显ST段。 |
| 关 键 词： | SD大鼠 心肌梗死模型 心电图 |
Method selection for the establishment of myocardial infarction model and the electrocardiographic presentation in the rats |
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| WANG Yong,GAO Da-zhong,YIN Yue-hui,SHE Qiang,GAO Cui-ju,ZhAO Jiang-long,TAN Yong,TANG Yong-gang,CHEN Yun-qing,LI Pan.Method selection for the establishment of myocardial infarction model and the electrocardiographic presentation in the rats[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(6):525-529,I0004. | |
| Authors: | WANG Yong GAO Da-zhong YIN Yue-hui SHE Qiang GAO Cui-ju ZhAO Jiang-long TAN Yong TANG Yong-gang CHEN Yun-qing LI Pan |
| Institution: | WANG Yong1,GAO Da-zhong2,YIN Yue-hui2,SHE Qiang2,GAO Cui-ju3,ZhAO Jiang-long4,TAN Yong1,TANG Yong-gang1,CHEN Yun-qing2*,LI Pan5(1.Department of Cardiovascular Diseases,The Seventh People's Hospital of Chongqing,Chongqing 400054,China,2.the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,3.General Hospital of Chongqing Iron and Steel Company,Chongqing 400080,4.People's Hospital of Baoji City,Baoji 721000,5.Ultrasonic Imaging Institute of Chongqing Medical University,Chongqing 4... |
| Abstract: | Objective To explore the site of left coronary artery ligation on establishing myocardial infarction model and the electrocardiographic features in those rat models.Methods After the Sprague-Dawley(SD) rats were anaesthetized and put on chine-assisted respiration,an occluding suture was placed at one of two distinct sites along the left coronary artery.The suture was placed about 3 mm distal to the aortic root(high) and about 2 mm distal to the horizontal line of left atrial appendage tip(low),respectively,... |
| Keywords: | Rat Model myocardial infarction Electrocardiogram |
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