Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion |
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Authors: | Vasiljeva Olga Turk Boris |
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Affiliation: | Department of Biochemistry and Molecular and Structural Biology, J. Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia. olga.vasiljeva@ijs.si |
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Abstract: | Cysteine cathepsins have been known for a long time to play an important role in cancer progression and metastasis. Several studies have proposed the concept of anti-cathepsin therapy in cancer treatment. On the other hand, cysteine cathepsins have been recently found to play a role in tumour cell death through mediation of apoptosis. The purpose of this mini-review is therefore to provide an insight into the mechanisms by which cysteine cathepsins modulate apoptosis and/or participate in tumour invasion, and to evaluate the impact of these enzymes on both tumour progression and development of potential strategies for cancer treatment. |
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Keywords: | Cysteine cathepsins Cancer progression Apoptosis Tumour invasion Cancer treatment |
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