Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration |
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Authors: | Carmo Helena de Boer Douwe Remião Fernando Carvalho Félix dos Reys Lesseps A de Lourdes Bastos Maria |
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Affiliation: | REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto. Rua Aníbal Cunha 164, 4050-047 Porto, Portugal. helenacarmo@ff.up.pt |
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Abstract: | 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers. |
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