肿瘤血管生成抑制剂的作用机制研究进展

肿瘤血管生成抑制剂批能破坏或抑制血管生成,有效地阻止肿瘤生长和转移的药物,可分为特异性和非特异性两大类。其作用机制主要有：（１）调控血管形成生长因子;（２）抑制基底膜降解;（３）影响信号转导通路;（４）调控细胞生长周期;（５）调控肿瘤机关基因。本文对其作用机制的进展作一综述。

Advances in the study of mechanisms of the tumor angiogenesis inhibitors

Tumor angiogenesis inhibitor is the drugs which can destroy or inhibit neovascularization, and block the growth and metastasis of cancer. For clinical applications it may be useful to divide the antiangiogenic drugs into two categories: class 1(specific inhibitors) and class 2 (non specific inhibitors).This review intends to provide the recent progress of the mechanisms of antiangiogenic drugs (1) Regulation of angiogenesis growth factors; (2) Inhibition of basement membrane degradation; (3) Mediating signal transduction pathway; (4) Effect of cell cycle; (5) Regulation of tumor related gene.