磁性纳米颗粒作为载体在基因转染中的研究进展

磁性纳米颗粒具有很强的结合、浓缩与保护DNA的作用，具有超顺磁性、较高的安全性和低的免疫原性，可以结合大片段DNA，在外加磁场的作用下可实现安全、高效的基因靶向性运输，提高外源基因的转染效率。由于磁性纳米颗粒的独特性质，使得其作为非病毒载体在基因治疗中的应用进展迅速。我们简要介绍磁性纳米材料的特点、种类及结构，磁性纳米基因载体的特点，以及磁性纳米颗粒作为载体在基因转染中的应用情况。

Progress of Magnetic Nanoparticles as Gene Vector

Magnetic nanoparticles had stronger ability to bind DNA. DNA and magnetic nanoparticles can form close and tight complex structure. The magnetic nanoparticles can protect DNA against the digestion of nuclease, which have some characteristics such as combination with big fragment DNA, low immunogenic, good biocompatibil-ity and targeted gene delivery by application of a magnetic field. Magnetic nanoparticles can improve transfection efficiency, achieve safe and efficient transport of gene. As a nonviral gene vector, the application of magnetic nanoparticles in gene therapy developed rapidly. In this article, we discussed the characteristics, varieties and struc-ture of magnetic nanoparticles, characteristics of magnetic nanoparticles as gene vector, the progress on magnetic nanoparticles as gene vector.