Noise-tolerant stimulus discrimination by synchronization with depressing synapses |
| |
Authors: | Fukai T Kanemura S |
| |
Institution: | (1) Department of Information–Communication Engineering, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan, JP;(2) CREST, JST (Japan Science and Technology), JP |
| |
Abstract: | Some synapses between cortical pyramidal neurons exhibit a rapid depression of excitatory postsynaptic potentials for successive
presynaptic spikes. Since depressing synapses do not transmit information on sustained presynaptic firing rates, it has been
speculated that they are favorable for temporal coding. In this paper, we study the dynamical effects of depressing synapses
on stimulus-induced transient synchronization in a simple network of inhibitory interneurons and excitatory neurons, assuming
that the recurrent excitation is mediated by depressing synapses. This synchronization occurs in a temporal pattern which
depends on a given stimulus. Since the presence of noise is always a potential hazard in temporal coding, we investigate the
extent to which noise in stimuli influences the synchronization phenomena. It is demonstrated that depressing synapses greatly
contribute to suppressing the influences of noise on the stimulus-specific temporal patterns of synchronous firing. The timing-based
Hebbian learning revealed by physiological experiments is shown to stabilize the temporal patterns in cooperation with synaptic
depression. Thus, the times at which synchronous firing occurs provides a reliable information representation in the presence
of synaptic depression.
Received: 5 July 2000 / Accepted in revised form: 12 January 2001 |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|