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Solid-phase synthesis of an arylsulfone hydroxamate library |
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| Authors: | Salvino J M Mathew R Kiesow T Narensingh R Mason H J Dodd A Groneberg R Burns C J McGeehan G Kline J Orton E Tang S Y Morrisette M Labaudininiere R |
| Affiliation: | Rhone Poulenc Rorer, Lead Discovery Department, Collegeville, PA 19426, USA. Jsalvino@aol.com |
| Abstract: | Synthesis of an arylsulfone hydroxamate lead optimization library is presented. Biological activity of representative examples is given to demonstrate the value of this approach for lead optimization. |
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