An analysis of aortic pressure curves taking into account visco-elastic properties of the aorta and variations in peripheral resistance |
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Authors: | Julia T Apter |
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Institution: | (1) Committee on Mathematical Biology, University of Chicago, Chicago, USA |
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Abstract: | The aortic pressure curve necessarily reveals the mechanical properties of the aorta and peripheral resistance as well as
of the dynamics of blood flow. The present study uses a reasonable model of visco-elastic properties of the aorta, a reasonable
form for variations in peripheral resistance and blood flow to predict an aortic pressure tracing. Numerical values of constants
measured experimentally were available in the published literature. These were used in the nonlinear differential equations
of motion of the system under analysis. The equations yielded to piece-wise solution, giving the aortic circumference and
the aortic pressure as functions of time. The form of both curves resembles clinical tracings, but numerical values of circumference
were higher and of pressure lower thanin vivo. The discrepancies between predicted and clinical curves may reveal certain inadequacies in published measurements on visco-elastic
constants. These measurements have been made on longitudinal rather than circumferential strips often containing dead rather
than living muscle. The discrepancies, therefore, indicate specific gaps in our knowledge of aortic behaviorin vitro. The suggested model of the system aided in the design of experiments which could supply data necessary to substantiate or
to revise the model. |
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