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Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists |
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| Authors: | Ahn Jin Hee Shin Mi Sik Jung Sun Ho Kim Jin Ah Kim Hye Min Kim Se Hoan Kang Seung Kyu Kim Kwang Rok Rhee Sang Dal Park Sung Dae Lee Jae Mok Lee Jeong Hyung Cheon Hyae Gyeong Kim Sung Soo |
| Affiliation: | Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon 305-600, Republic of Korea. jhahn@krict.re.kr |
| Abstract: | A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARgamma. The best PPARgamma agonist in this series was 9h, which showed an EC(50) value of 15 nM. |
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