Nonrandom chromosome changes in nine rat liver epithelial cell lines |
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| Affiliation: | 1. Laboratoire de Biochimie Médicale, d''Embryologie et de Cytogénétique, Faculté de Médecine, 21033 Dijon, France;2. Laboratoire d''Histologie, d''Embryologie et de Cytogénétique, Faculté de Médecine, 21033 Dijon, France |
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| Abstract: | Using G-banding technique, the karyotypes of nine liver epithelial cell lines from Wistar rats cultivated under standard conditions were studied in early successive passages. Preferential involvement of chromosome n∘ 1 abnormalities including numerical and structural changes appeared at about the 14th passage. These apparently nonrandom chromosome changes have been compared with those found in neoplastic cell lines. |
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