Lactate dehydrogenase isozymes of the leopard danio,Brachydanio nigrofasciatus: their characterization and ontogeny |
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Affiliation: | 1. Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 457-8601, Japan;2. Department of Endocrinology and Diabetology, Nagoya City University East Medical Center, 1-2-23 Wakamizu, Chikusa-ku, Nagoya, 464-8547, Japan;1. Laboratory for Neural Circuit Dynamics of Decision-making, RIKEN Center for Brain Science, Saitama 351-0198, Japan;2. Department of Life Sciences, Graduate School of Arts and Science, The University of Tokyo, Tokyo 153-8902, Japan;3. RIKEN CBS-Kao Collaboration Center, Saitama 351-0198, Japan;4. Research Resources Division, RIKEN Center for Brain Science, Saitama 351-0198, Japan;5. Lead contact |
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Abstract: | - 1.1. The tissue specific patterns and ontogeny of lactate dehydrogenase (LDH) are reported.
- 2.2. While all tissues (eye, brain, heart, intestine, liver, ovary and skeletal muscle) show isozymes of A and B subunit composition, only liver extracts possess isozymes resulting from C subunit synthesis.
- 3.3. The A4 homopolymer appears simultaneously with initial muscle contractility and is correlated with the physiological function of muscular contraction.
- 4.4. The activation of the Ldh-C locus is correlated with the first functioning of liver. It is suggested that the state of differentiation of liver cells may be the stimulus required for C locus expression.
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