Effect of lead chromate on chromosome aberration,sister-chromatid exchange and DNA damage in mammalian cells in vitro |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Road, Phayathai, Ratchathewi, Bangkok, Thailand;2. Escola Universitària Salesiana de Sarrià, Passeig Sant Joan Bosco, 74, 08017, Barcelona, Spain;3. Universidad del Quindío, Carrera 15 Calle 12 Norte-P.Box, 630004, Armenia, Colombia;1. Irstea, UR HBAN – Artemhys, CS 10030, 92761 Antony cedex, France;2. Federation of Research FIRE, FR-3020, 75005 Paris, France;3. Ifremer, 92138 Issy-les-Moulineaux, France |
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| Abstract: | Possible mutagenic activity of lead chromate in mammalian cells was studied using assays for chromosome aberrations and sister-chromatid exchanges in cultured human lymphocytes, and DNA fragmentation as detected by alkaline-sucrose gradient sedimentation in cultured Chinese hamster ovary (CHO) cells. Lead chromate caused dose-related increases in chromosome aberration and sister-chromatid exchange in human lymphocytes. No increase in DNA damage was observed in CHO cells, possibly due to the relative insensitivity of the CHO cells and the limited solubility of lead chromate in tissue culture medium. The mutagenicity of lead chromate in human lymphocytes appears to be entirely due to the chromate ion since chromosome aberrations were induced by potassium chromate but not lead chloride. |
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