Effects of IGF-I on proliferation and steroidogenesis of cultured adrenal zona glomerulosa cells |
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| Authors: | N Horiba K Nomura N Hizuka K Takano H Demura K Shizume |
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| Institution: | Department of Medicine, Tokyo Women's Medical College, Japan. |
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| Abstract: | In a primary culture of bovine adrenal zona glomerulosa cells, insulin-like growth factor I (IGF-I)/somatomedin C stimulated DNA synthesis, as measured by 3H] thymidine uptake, at concentrations of 10(-9) and 10(-7) M. IGF-I also prevented ACTH-induced suppression of 3H] thymidine uptake. IGF-I in no way affected aldosterone secretion during short-term exposure to cultured cells, however. Our findings suggest that IGF-I plays an important role in the proliferation of adrenal zona glomerulosa cells. |
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