Somatostatin acts through G-proteins on dopaminergic adenylate cyclase in the caudate-putamen of the rat |
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Authors: | Andreas Moser Hinrich Cramer |
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Affiliation: | (1) Dept. of Neurology, Med. University of Lübeck, Ratzeburger Allee 160, D-2400 Lubeck, FRG;(2) Dept. of Neurology, University of Freiburg, Hansastr. 9, D-7800 Freiburg, FRG |
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Abstract: | Somatostatin was incubated in an adenylate cyclase assay of a particulate fraction of caudateputamen tissue of the rat in order to examine the effect of the peptide on D-1 receptor coupled adenylate cyclase in vitro. Somatostatin was able to enhance cyclic AMP formation in the presence of guanylylimidodiphosphate and guanosine-triphosphate. In contrast to this, somatostatin inhibited both dopamine and forskolin-stimulated cyclic AMP accumulation. Pertussis toxin and cholera toxin also depressed forskolin-induced stimulation. Somatostatin was found to antagonize these inhibitory effects of pertussis toxin and cholera toxin. The results suggest that somatostatin acts through a stimulatory as well as an inhibitory guanine nucleotide regulatory protein subtype to affect dopaminergic adenylate cyclase activity. |
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Keywords: | Adenylate cyclase somatostatin G-proteins caudate-putamen rat |
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