Ubiquitylation and autophagy in the control of bacterial infections and related inflammatory responses |
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Authors: | Ligeon Laure-Anne Temime-Smaali Nassima Lafont Frank |
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Institution: | Cellular Microbiology of Infectious Pathogens, Lille Center for Infection and Immunity, CNRS UMR8204, INSERM U1019, University of Lille Nord-de-France, Institut Pasteur de Lille, F-59019 Lille, France. |
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Abstract: | The ubiquitin proteasome system and autophagy constitute key signalling pathways in the host response to infection. The identification of adaptors linking the two pathways has prompted a re-examination of the latter's involvement in inflammatory reactions and the clearance of bacteria. The ubiquitin-autophagy pathway is a preferred target for effectors from pathogens that seek to exploit and evade the host defence mechanisms. A number of new players and signalling nodes have recently been identified. Here, we discuss these new insights into the host's control of bacterial infection. |
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