Microinjection of normal cell extracts into Fanconi anemia fibroblasts corrects defective scheduled DNA synthesis recovery after 8-methoxypsoralen plus UVa treatment |
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| Authors: | M. M. Gök E. Wunder |
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| Affiliation: | (1) Institut für Anthropologie und Humangenetik der Universität, Im Neuenheimer Feld 328, D-6900 Heidelberg, Federal Republic of Germany;(2) Present address: Section Biologie, Institut Curie, 26, rue d'Ulm, F-75231 Paris, France |
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| Abstract: | Summary Fanconi anemia (FA) cells show an increased sensitivity to 8-methoxypsoralen (8-MOP) plus UVa treatment; after an initial reduction of their semiconservative DNA synthesis rate, they do not recover like normal cells. We microinjected extracts from normal cells into FA fibroblasts from complementation group A and determined semiconservative DNA synthesis rates by autoradiography; the hampered recovery phase was completely restored.The present data are part of M. Gök's thesis 1987 at the University of Heidelberg |
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