Antiviral Effects of Novel Herbal Medicine KIOM-C,on Diverse Viruses |
| |
| Authors: | Melbourne R Talactac Mohammed Y E Chowdhury Min-Eun Park Prasanna Weeratunga Tae-Hwan Kim Won-Kyung Cho Chul-Joong Kim Jin Yeul Ma Jong-Soo Lee |
| |
| Institution: | 1. College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.; 2. College of Veterinary Medicine and Biomedical Sciences, Cavite State University, Cavite, Philippines.; 3. Faculty of Veterinary Medicine, Chittagong Veterinary and Animal Sciences University, Chittagong, Bangladesh.; 4. Korean Medicine (KM) Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Deajeon, and Republic of Korea.; The University of Chicago, UNITED STATES, |
| |
| Abstract: | In order to identify new potential antiviral agents, recent studies have advocated thorough testing of herbal medicines or natural substances that are traditionally used to prevent viral infections. Antiviral activities and the mechanism of action of the total aqueous extract preparation of KIOM-C, a novel herbal medicine, against diverse types of viruses were investigated. In vitro antiviral activity against A/Puerto Rico/8/34 (H1N1) (PR8), vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) through the induction of type-I interferon related protein phosphorylation and up-regulation of pro-inflammatory cytokines in murine macrophage cells (RAW264.7) were determined. In vivo, KIOM-C-treated BALB/c mice showed higher survivability and lower lung viral titers when challenged with A/Aquatic bird/Korea/W81/2005 (H5N2), A/PR/8/34(H1N1), A/Aquatic bird/Korea/W44/2005(H7N3) or A/Chicken/Korea/116 /2004(H9N2) influenza subtypes in contrast with the non-treated group. The present study revealed that total aqueous extract preparation of KIOM-C stimulates an antiviral state in murine macrophage cells and in mice leading to inhibition of viral infection and protection against lethal challenges. |
| |
| Keywords: | |
|
|
