A new twist on clock protein phosphorylation: a conformational change leads to protein degradation |
| |
Authors: | Menet Jerome S Rosbash Michael |
| |
Institution: | Department of Biology, National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, MA 02454, USA. |
| |
Abstract: | Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth et?al. (2011) demonstrate that phosphorylation of Neurospora FRQ induces?a conformational change, which can account for its temporally gated degradation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|