A new twist on clock protein phosphorylation: a conformational change leads to protein degradation |
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| Authors: | Menet Jerome S Rosbash Michael |
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| Institution: | Department of Biology, National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, MA 02454, USA. |
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| Abstract: | Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth et?al. (2011) demonstrate that phosphorylation of Neurospora FRQ induces?a conformational change, which can account for its temporally gated degradation. |
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