A new investigation for some steroidal derivatives as anti-Alzheimer agents |
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Authors: | Abdalla Mohamed M Al-Omar Mohamed A Al-Salahi Rashad A Amr Abdel-Galil E Sabrye Nermien M |
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Institution: | Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt. |
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Abstract: | We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their β-amyloid (Aβ) lowering results as IC(50) values reported. |
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