Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides |
| |
| Authors: | Rajakumar Perumal Padmanabhan Ramar Rajesh Navin |
| |
| Affiliation: | Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India. perumalrajakumar@gmail.com |
| |
| Abstract: | A series of bis-oxy cyclophane diamides with bis(aminomethyl)m-terphenyl as spacer have been synthesized and characterized from spectral and analytical data. All the cyclophane diamides exhibit better anti-arthritic activity than the reference drug viz. diclofenac sodium. Some of the cyclophane diamides exhibit good anti-inflammatory activity. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
