Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA.
Abstract:
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Highlights? Switching in sharks consistent with immunization and cytidine deaminase expression ? Isotype switching can be reciprocal between genes of established positions ? Switch joints show DNA double-strand breakage repaired by nonhomologous end-joining ? Unlike in tetrapods, switching in shark is bidirection between IgM and IgW
