Multiplexed RNA trafficking in oligodendrocytes and neurons |
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| Authors: | Carson John H Gao Yuanzheng Tatavarty Vedakumar Levin Mikhail K Korza George Francone Victor P Kosturko Linda D Maggipinto Michael J Barbarese Elisa |
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| Affiliation: | Department of Molecular Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. |
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| Abstract: | In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons. |
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