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Serological Analysis of the Repertoire of Human Cancer Antigens and Autoantigens |
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| Authors: | Koroleva E. P. Lagarkova M. A. Khlgatian S. V. Shebzukhov Yu. V. Mescheryakov A. A. Lichinitser M. R. Nedospasov S. A. Kuprash D. V. |
| Affiliation: | (1) Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia;(2) Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119899, Russia;(3) Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia |
| Abstract: | The spectrum of human antigens allows a monitoring of various pathological processes such as autoimmune disorders and tumorigenesis. Serological analysis of cDNA expression libraries (SEREX) is now used to search for new cancer-associated antigens, which are potential diagnostic markers or targets for immunotherapy of cancer. The results obtained for several solid tumors are reviewed. Groups of antigens detectable by SEREX, causes of immunogenicity of autoantigens, and prospective implication of antigens in diagnostics and monitoring of cancer are discussed. |
| Keywords: | autoantigens cancer immunodiagnostics expression libraries cDNA |
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