Comprehensive computational analysis of Hmd enzymes and paralogs in methanogenic Archaea |
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| Authors: | Aaron D Goldman John A Leigh Ram Samudrala |
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| Affiliation: | (1) Department of Microbiology, University of Washington, Seattle, WA, USA;(2) NSF IGERT Program in Astrobiology, University of Washington, Seattle, WA, USA |
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| Abstract: | Background Methanogenesis is the sole means of energy production in methanogenic Archaea. H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd) catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens. At least one hmd paralog has been identified in nine of the eleven complete genome sequences of class I hydrogenotrophic methanogens. The products of these paralog genes have thus far eluded any detailed functional characterization. |
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