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Proteomic analysis of total cellular proteins of human neutrophils |
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| Authors: | Gisele G Tomazella Idalete da Silva Helen J Laure José C Rosa Roger Chammas Harald G Wiker Gustavo A de Souza Lewis J Greene |
| Institution: | 1. Centro de Química de Proteínas, Centro Regional de Hemoterapia e Faculdade de Medicina de Ribeir?o Preto, Universidade de S?o Paulo, 14049-900, Ribeir?o Preto, Brasil 2. Departmento de Bioquímica Disciplina de Biologia Molecular, Universidade Federal de S?o Paulo, S?o Paulo, Brasil 3. Laboratório de Oncologia Experimental LIM/24, Faculdade de Medicina, Universidade de S?o Paulo, S?o Paulo, Brasil 4. Section for Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen, Norway |
| Abstract: | BackgroundNeutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of human neutrophil proteins in various subcellular membrane and granular fractions. Although there are relatively few studies dealing with the analysis of the total extract of human neutrophils, many biological problems such as the role of chemokines, adhesion molecules, and other activating inputs involved in neutrophil responses and signaling can be approached on the basis of the identification of the total cellular proteins. |
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