A role for ferrous ion and oxygen in the degradation of DNA by bleomycin. |
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| Authors: | E A Sausville J Peisach S B Horwitz |
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| Institution: | 1. Department of Pharmacology Albert Einstein College of Medicine Bronx, New York 10461 USA;2. Department of Cell Biology Albert Einstein College of Medicine Bronx, New York 10461 USA;3. Department of Molecular Biology Albert Einstein College of Medicine Bronx, New York 10461 USA |
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| Abstract: | An interaction between bleomycin and low concentrations of Fe(II) in the degradation of DNA is reported. Complete conversion of simian virus 40 DNA to acid-soluble products occurs at approximately equimolar levels of Fe(II), bleomycin, and DNA; Fe(III) does not substitute for Fe(II) in this reaction. Anaerobiosis inhibits the observed DNA degradation by bleomycin and Fe(II). Optical spectral studies reveal that an oxygen-labile complex is formed between bleomycin and Fe(II). |
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