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Activation of ryanodine receptors by flash photolysis of caged Ca2+. |
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| Authors: | G D Lamb and D G Stephenson |
| Abstract: | Flash photolysis of DM-nitrophen generates an extremely large [Ca2+] transient ("Ca2+ spike") at the start of each Ca2+ "step." The Ca2+ spike greatly increases the speed of activation of the ryanodine receptor channel ("supercharging") and could be responsible for apparent channel adaptation. |
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