Haloperidol modulates ion transport in <Emphasis Type="Italic">Chara corallina</Emphasis> cells |
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Authors: | O M Zherelova A A Kataev V M Grischenko R Sh Shtanchaev |
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Institution: | 1.Institute of Theoretical and Experimental Biophysics,Russian Academy of Sciences,Pushchino, Moscow oblast,Russia;2.Institute of Cell Biophysics,Russian Academy of Sciences,Pushchino, Moscow oblast,Russia;3.Institute of Biological Instrumentation,Russian Academy of Sciences,Pushchino, Moscow oblast,Russia |
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Abstract: | The effects of haloperidol, an antagonist of D2 dopamine receptors, on the functioning of Ca2+, K+, and Cl? ion channels in the membrane of Chara corallina cells and on the functional properties of their cytoskeleton was studied. Haloperidol blocked Ca2+ channels of the plasmalemma. In addition to bringing about a decrease in the amplitude of the calcium current, exposure to haloperidol decelerated the activation and inactivation of calcium channels. The effect of haloperidol was reversible; after it was removed, the characteristics of calcium current were restored. Haloperidol did not affect Ca2+-activated chloride channels. Haloperidol also inhibited microfilament-dependent motion of the cytoplasm. Cytoplasmic streaming was restored after haloperidol was removed from the extracellular solution. These results suggest that the concentration of free Ca2+ ions in the cytoplasm increases in the presence of haloperidol, and that Ca2+ channels of C. corallina plasmalemma possess specific binding sites both for dopamine receptors and for their antagonists. |
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