Effects of selenium supplementation on virus-induced inflammatory heart disease |
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Authors: | Nils-Gunnar Ilbäck Jan Fohlman Göran Friman |
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Institution: | (1) Toxicology Division, National Food Administration, Uppsala, Uppsala University Hospital, Uppsala, Sweden;(2) Department of Infectious Diseases, Uppsala University Hospital, Uppsala, Sweden |
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Abstract: | The effects of 10 wk of selenium (Se) supplementation (5 ppm) in drinking water on immune responses and resistance to a myocarditic
Coxsackie virus B3 (CB3) infection were studied in female Balb/c mice. Se supplementation reduced CB3-induced mortality: at
day 14 postinoculation, survival was 58% in the Se-treated group as compared to 25% in the untreated group. Whole-blood glutathione
peroxidase (GSH-Px) activity was elevated by 68% (p < 0.001) and Se content in the liver by 24% (p < 0.001). Red (RBC) and white blood cell (WBC) counts, as well as the number
of cells in the spleen and thymus, were unaffected. The cellular counts of T-lymphocytes (CD4+, CD8+) and natural killer (NK+) cells in the blood were not affected. However, the CD4+/CD8+ ratio (5.2) tended to increase after Se supplementation (5.9). The spleen lymphoproliferative response to T and B-cell mitogens
were increased by 9 and 43%, respectively (ns), in the Se-supplemented group. The total NK cell activity in blood and spleen
showed minor increases, but when the activity in the blood was expressed per cell, the increase amounted to 35% (ns) with
Se supplementation. The inflammatory and necrotic lesions in the ventricular myocardium at 7 and 14 d postinoculation were
not significantly reduced by Se treatment, probably owing to the increased survival with Se even of mice with the most pronounced
heart damage; comparable untreated mice were estimated to have died at day 14. Results indicate that modest doses of Se can
improve immune function, which may increase the general resistance to this viral infection. |
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Keywords: | Heart immunology inflammation mouse selenium virus |
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