Developmental changes of the glycolytic enzymes in the human fetal heart |
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Authors: | Jayati Das Gupta Trishna Sengupta Chhabi Dutta Kathakali De S De D Sengupta |
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Institution: | (1) Department of Biochemistry, University College of Science, Calcutta University, 35, Ballygunge Circular Road, 700 019 Calcutta, India |
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Abstract: | The ontogeny of hexokinase, phosphofructokinase, phosphoglucoisornerase, aldolase, pyruvate kinase and lactate dehydrogenase
activities which are associated with glycolysis, an important energy yielding process, has been studied in human fetal heart
for periods ranging from 13 weeks to above 33 weeks of gestation. Hexokinase, phosphoglucoisomerase and pyruvate kinase activities
show similar developmental profiles exhibiting maximum activity at 25–28 weeks ofgestation. Phosphofructokinase activity,
on the other hand, shows a minimum at this period and exhibits a peak value at early stages (13–16 weeks of gestation). Though
considerable activity for aldolase is observed at an early period, it declines thereafter, but again increases in the later
period. The probable role and correlations of these glycolytic enzymes with energy demand and general functional development
in human fetal heart in ontogeny are evaluated. |
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Keywords: | Glycolysis hexokinase phosphoglucoisomerase phosphofructokinase aldolase pyruvate kinase lactate dehydrogenase human fetal heart development |
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