Hormone-regulated expression of cellular rasH oncogene in mammary carcinomas in rats |
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Authors: | F L Huang Y S Cho-Chung |
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Institution: | Cellular Biochemistry Section Laboratory of Pathophysiology National Cancer Institute Bethesda, Maryland 20205 USA |
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Abstract: | Differential gene expression has been observed in hormone-dependent rat mammary carcinomas during their growth and regression. A 22K MW protein, a prominent in vitro translation product of the growing as compared to the regressing tumor, was identified as the c-rasH-21,000-dalton transforming protein (p21) using a monoclonal antibody that reacts specifically with Harvey-related p21 species. The amount of p21-translated protein sharply decreased in the translation products of the regressing tumors within 6 hours post ovariectomy or dibutyryl cyclic AMP treatment. The results show that an enhanced expression of the c-rasH oncogene is associated with hormone-dependent growth of mammary carcinomas in vivo and that suppression of this oncogene precedes the tumor regression induced by either hormone withdrawal or dibutyryl cyclic AMP treatment. |
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Keywords: | To whom requests for reprints should be sent |
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