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Quantitative structure-activity relationship study on sulfanilamide schiff's bases: carbonic anhydrase (CA) inhibitors |
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| Authors: | Agrawal Vijay K Srivastava Shachi Khadikar Padmakar V Supuran Claudiu T |
| Affiliation: | a QSAR and Computer Chemical Laboratories, A.P.S. University, Rewa-486 003, India b Research Division, Laxmi Fumigation and Pest Control Pvt. Ltd., 3 Khatipura, Indore-452 007, India c University of Florence, Dipartmento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia, 3, RM.188, Polo Scientifico, 50019-Sesto Fiorentino (, Firenze), Italy |
| Abstract: | The paper deals with quantitative structure–activity studies on a group of sulfanilamide Schiff's base inhibitors of carbonic anhydrase (CA) using distance-based topological indices. The regression analysis of the data has shown that the activities of the compounds used in inhibiting Carbonic AnhydraseII (CAII) activity can be modeled excellently in multi-parametric model in that some indicator parameters are also involved. The results are discussed critically. |
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