Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex |
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| Authors: | Chee Choy Kok Emma J Croager Campbell S Witt Lynette Kiers Frank L Mastaglia Lawrence J Abraham M J Garlepp |
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| Institution: | (1) Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, AU;(2) Department of Biochemistry, University of Western Australia, Nedlands, Western Australia, AU;(3) Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, AU;(4) Department of Clinical Immunology, Royal Perth Hospital, Western Australia., AU;(5) Department of Biochemistry, University of Western Australia, Nedlands, Western Australia, AU;(6) Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia, AU;(7) School of Pharmacy, Curtin University of Technology, GPO Box U 1987, Perth 6845, Western Australia E-mail: tgarlepp@cc.curtin.edu.au, Tel.: +61-8947 04078, Fax: +61-8926 62769, AU |
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| Abstract: | Inclusion body myositis (IBM) is a form of idiopathic inflammatory myopathy of unknown aetiology. A strong association with
HLA class II (HLA-DR3) suggested a role for genes in the human major histocompatibility complex (MHC) in the predisposition to this disease. In
this study, we have taken advantage of the ancestral haplotype (AH) concept and historical recombinations to map for a possible
susceptibility gene(s) in the MHC. We performed detailed typing of three MHC-related HSP70 genes and defined allelic combinations in the context of MHC AH. We also modified existing methods to give a simple and accurate
method for typing two TNF microsatellites. Using the HSP70 and TNF markers and HLA-DR, –B, and C4 typing of our patients with IBM, we defined a potential site for the MHC-associated susceptibility gene(s) in the region
between HLA-DR and C4.
Received: 16 July 1998 / Revised: 14 January 1999 |
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| Keywords: | Inclusion body myositis Ancestral haplotypes MHC HSP70 TNF Microsatellites |
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