Kinetic resolution of a diltiazem intermediate by lipase-catalyzed enantioselective alcoholysis |
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Authors: | Michal Shapira-Levinger Ayelet Fishman |
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Affiliation: | IMI (TAMI) Institute for Research and Development, P.O.B 10140, Haifa Bay 26111, Israel |
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Abstract: | A novel enzymatic resolution of an important alcohol intermediate in the Diltiazem process was developed. The enzymatic reaction involved alcoholysis of the alcohol acetate with butanol, thus obtaining the (R,R)-alcohol and the remaining (S,S)-acetoxy-alcohol in >95% enantiomeric excess. This resolution may serve as the key step in a possible recycling procedure for the waste streams of the Diltiazem process, which will allow a significant increase in the overall process yield. |
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Keywords: | Diltiazem Lipases Porcine liver acetone powder Alcoholysis Resolution |
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