Fluoxetine subsensitizes a nicotinic mechanism involved in the regulation of core temperature |
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| Authors: | S C Dilsaver R K Davidson |
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| Institution: | 1. University of Texas Health Science Center at Houston (UTHealth), School of Public Health, Austin Campus, 1616 Guadalupe Street, Suite 6.300, Austin, TX 78701, USA;2. The University of Oklahoma Health Sciences Center, Oklahoma Tobacco Research Center, 655 Research Parkway, Suite 400, Oklahoma City, OK 73104, USA;3. University of Texas at Austin, Population Research Center, 305 E. 23rd Street, Stop G1800, Austin, TX 78712, USA;1. Chronobiology Laboratory, Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain;2. Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Switzerland;3. Department of Psychology, Division of Clinical Psychology and Epidemiology, University of Basel, Switzerland;4. Department of Ophthalmology, University of Basel, Switzerland |
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| Abstract: | Fluoxetine HCl, 10 mg/kg ip, twice daily produced subsensitivity to the hypothermic effects of nicotine (base), 1 mg/kg ip, after 1 (p less than 0.02) and 2 (p less than 0.002) weeks of treatment. Phenelzine sulfate, desipramine HCl and bright artificial light produced the same effect. The capacity of three chemically distinct classes of antidepressants and bright artificial light (a treatment for seasonal depression) to produce this result suggests that effects on nicotinic mechanisms may be involved in the mechanism of action of these treatments. |
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