| Abstract: | The paper is concerned with the data indicating close interaction between xanthinoxidase (Xase) and phosphodiesterase (PDE). PDE activity can be modified by affecting the activity of Xase. This effect is mediated by changes in the concentrations of endogenous xanthines. The action of PDE inhibitors, methylxanthines, is discussed from the point of view of the above effect. The data obtained hold promise for purposeful monitoring of tissue concentrations of the cyclic nucleotides in vivo and in vitro. |
