Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation |
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| Authors: | Hassan Hida Charles Coudray Jean Calop Alain Favier |
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| Institution: | (1) Groupe de Recherche sur les Pathologies Oxydatives (GREPO), Laboratoire de Pharmacie Clinique et Biotechniques, UJF, Faculté de Pharmacie, La Tronche, France;(2) Groupe de Recherche sur les Pathologies Oxydatives (GREPO), Laboratoire de Biochimie des Micronutriments et Radicaux Libres, CHRU de Grenoble, BP 217X, 38043 Grenoble Cedex, France |
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| Abstract: | Adriamycin (25 μM) stimulated NADPH-dependent microsomal lipid peroxidation about fourfold over control values. The tested antioxidants, zinc,
superoxide dismutase, vitamin E, and desferrioxamine (Desferal) inhibited Adriamycin-enhanced lipid peroxidation to varying
degrees. Others antioxidants, e.g., glutathione, catalase, and selenium, were found to have no effects. Our in vitro studies
suggest that adriamycin effect is mediated by a complex oxyradical cascade involving superoxide, hydroxyl radical, and small
amounts of iron. |
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| Keywords: | Adriamycin lipid peroxidation microsomes antioxidants |
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