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Membrane-anchored peptide inhibits human immunodeficiency virus entry |
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| Authors: | Hildinger M Dittmar M T Schult-Dietrich P Fehse B Schnierle B S Thaler S Stiegler G Welker R von Laer D |
| Institution: | Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universit?t Hamburg, Germany. |
| Abstract: | Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage. |
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