A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria <em>versus</em> endoplasmic reticulum期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

*A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria versus* endoplasmic reticulum**

Authors:	Haidar Akl Tamara Vervloessem Santeri KiviluotoMart Bittremieux Jan B. ParysHumbert De Smedt Geert Bultynck

Affiliation:	KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Medicine, Campus Gasthuisberg, O/N-I, Bus 802, Herestraat 49, BE-3000 Leuven, Belgium

Abstract:

Keywords:	ATP, adenosine triphosphate BI-1, Bax inhibitor-1 BH, Bcl-2-homology CN, calcineurin CaM, calmodulin CLL, chronic lymphocytic leukemia JNK1, c-Jun N-terminal kinase 1 DLBCL, diffuse large B-cell lymphoma DARPP-32, dopamine- and cAMP-regulated phosphoprotein of 32 kDa ER, endoplasmic reticulum ERK, extracellular-signal-regulated kinases GM-CSF, granulocyte&ndash macrophage colony-stimulating factor IP₃R, inositol 1,4,5-trisphosphate receptor IRE1α, inositol-requiring enzyme-1 alpha IL-2 and IL-3, interleukin (IL)-2 and -3 IICR, IP₃-induced Ca²⁺ release MAMs, mitochondria-associated ER membranes MOMP, mitochondrial outer membrane permeabilization NFAT, nuclear factor of activated T-cells PTEN, phosphatase and tensin homolog PI3K, phosphatidylinositol 4,5-bisphosphate 3-kinase Akt/PKB, phosphoinositide-dependent serine&ndash threonine protein kinase/protein kinase B PKA, protein kinase A SERCA, sarco/endoplasmic reticulum Ca²⁺-ATPase TAT-IDP^S, stabilized TAT-IP₃R-derived peptide Orai1, STIM1-mediated Ca²⁺-release-activated Ca²⁺-channel protein 1 STIM1, stromal interaction molecule 1 UPR, unfolded protein response VDAC, voltage-dependent anion channel
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