Characterization of novel store-operated calcium entry effectors |
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Authors: | Alaeddine Djillani,Oliver Nü ß eOlivier Dellis |
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Affiliation: | University of Paris-Sud, Bâtiment 440/443, rue des Adèles, Orsay 91405, France; INSERM UMR-S 757, Bâtiment 440/443, rue des Adèles, Orsay 91405, France |
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Abstract: | 2-Aminoethyl diphenylborinate (2-APB) is a well-known effector of the store-operated Ca2 + entry of several cell types such as immune cells, platelets and smooth muscle cells. 2-APB has a dual effect: potentiation at 1–5 μM and inhibition at > 30 μM. Unfortunately, it is also able to modify the activity of other Ca2 + transporters and, thus, cannot be used as a therapeutic tool to control the leukocyte activity in diseases like inflammation. Previously, we have shown that SOCE potentiation by 2-APB depends on the presence of the central boron-oxygen core (BOC) and that the phenyl groups determine the sensitivity of the molecule to inhibit and/or potentiate the SOCE. |
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Keywords: | 2-APB, 2-aminoethyl diphenylborinate SOCE, store-operated calcium entry BOC, boron-oxygen core IL-2, interleukin 2 |
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