Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

Authors:	Mariya Misheva Gurpreet Kaur Kevin R.W. Ngoei Yvonne Y. Yeap Ivan H.W. Ng Kylie M. Wagstaff Dominic C.H. Ng David A. Jans Marie A. Bogoyevitch

Affiliation:	1. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia;2. Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia;3. European Molecular Biology Laboratory (EMBL) Australia, Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia

Abstract:

Keywords:	MAPK, mitogen-activated protein kinase ERK, extracellular signal-regulated kinase JNK, c-Jun N-terminal kinase Imp, importin NLS, nuclear localization sequence NTS, nuclear translocation signal FRAP, fluorescence recovery after photobleaching GFP, green fluorescent protein GST, glutathione S-transferase MKK, MAPK kinase IAF, 5-iodoacetamidofluorescein HTC cells, rat hepatoma tissue culture cells CLSM, confocal laser scanning microscopy TR70, Texas Red-labeled dextran MEFs, murine embryonic fibroblasts p45, nuclear factor erythroid 2 (NF-E2) TAg, Simian Virus SV40 large tumor antigen Fn, nuclear fluorescence Fc, cytoplasmic fluorescence Fn/c, the nuclear to cytoplasmic ratio t_1/2, time to reach half-maximal recovery SEM, standard error of the mean
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